Premium
Palladium‐Catalyzed ortho ‐Acylation of Acetanilides with Aldehydes through Direct CH Bond Activation
Author(s) -
Li Chengliang,
Wang Lei,
Li Pinhua,
Zhou Wei
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201101192
Subject(s) - acetanilide , acylation , catalysis , chemistry , palladium , organic chemistry , medicinal chemistry , combinatorial chemistry
Easy access to o ‐acyl acetanilides : A new Pd‐catalyzed ortho ‐acylation of acetanilides with both aromatic and aliphatic aldehydes has been developed based on a CH activation process. In the presence of tert ‐butyl hydroperoxide (TBHP) as the ideal oxidant, this reaction provides an efficient access to ortho ‐acyl acetanilides in good yields (see scheme).