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Site‐Specific Recognition of Guanosine by Manganese(III) Corroles in DNA Non‐Duplex Regions through Active Oxygen Transfer
Author(s) -
Zhai Qianqian,
Xu Liang,
Ge Yushu,
Tian Tian,
Wu Wendi,
Yan Shengyong,
Zhou Yangyang,
Deng Minggang,
Liu Yi,
Zhou Xiang
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201101128
Subject(s) - duplex (building) , guanosine , dna , cleavage (geology) , chemistry , biophysics , manganese , combinatorial chemistry , biology , biochemistry , paleontology , organic chemistry , fracture (geology)
DNA damage plays an important role in cellular processes. Besides natural protein nucleases, different types of efficient agents for DNA damage have been developed over recent decades in the search for new anticancer and antiviral drugs. In addition to the double‐stranded configuration, DNA structures also include some non‐duplex regions, which are considered to be from spontaneous errors in DNA replication, thus playing an important role for cells. Herein, we focused on these non‐duplex regions of DNA and generated manganese(III) corroles, which exhibit a highly selective cleavage ability for guanosine units located at non‐duplex portions, such as loops and bulges. The cleavage mechanism was demonstrated to be a manganese‐induced oxidation process. The results given herein show a molecular approach that could specifically probe the guanosine units in DNA non‐duplex structures, thus representing a promising step in the construction of tools to target non‐duplex structures in chromosomes.