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Highly Porous, Water‐Soluble, Superparamagnetic, and Biocompatible Magnetite Nanocrystal Clusters for Targeted Drug Delivery
Author(s) -
Dong Fuping,
Guo Wanping,
Bae JaeHo,
Kim SunHee,
Ha ChangSik
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201101110
Subject(s) - magnetite , superparamagnetism , biocompatibility , nanocrystal , chemical engineering , materials science , drug delivery , targeted drug delivery , porosity , nanotechnology , drug carrier , particle size , nanoparticle , trisodium citrate , magnetization , metallurgy , composite material , physics , quantum mechanics , magnetic field , engineering
Magnetic particles have become very promising materials for drug delivery. However, preparation of magnetite particles with high surface area, biocompatibility, strong magnetic response, and suitable particle size still remains a major challenge. In this report, magnetite nanocrystal clusters with high surface areas were fabricated through a solvothermal process by introducing ammonium acetate as a porogen and trisodium citrate as a surface modification agent. The porosity, which was controlled by the reactant concentration, has been investigated in detail. The surface area of the nanocrystal clusters was as high as 141 m 2 g −1 . Ibuprofen, as a model drug, was entrapped into the magnetite carriers. The interfacial interaction between the carboxylic groups on the drug molecules and the carboxylate groups on the carriers enhanced the loading efficiency. Low cytotoxicity in MCF‐7 cell and in vitro constant drug release behavior combined with the high drug loading efficiency and high saturation magnetization values demonstrated the potential of the as‐synthesized magnetite materials in targeted drug release systems.