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A General Cyclocarbonylation of Aryl Bromides and Triflates with Acetylenes: Palladium‐Catalyzed Synthesis of 3‐Alkylidenefuran‐2‐ones
Author(s) -
Wu XiaoFeng,
Sundararaju Basker,
Anbarasan Pazhamalai,
Neumann Helfried,
Dixneuf Pierre H.,
Beller Matthias
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201101083
Subject(s) - aryl , palladium , carbonylation , generality , combinatorial chemistry , function (biology) , scheme (mathematics) , catalysis , chemistry , process (computing) , computer science , organic chemistry , programming language , psychology , mathematics , biology , carbon monoxide , alkyl , evolutionary biology , psychotherapist , mathematical analysis
Making use of CO : An improved efficient synthesis of 5‐aryl‐3‐alkylidenefuran‐2‐ones has been developed (see scheme). Starting from readily available (hetero)aryl bromides or aryl triflates and alkynes, furanones were produced in good yields through a double carbonylation process. To illustrate the generality of the method more than 25 furanone derivatives were synthesized, including the permethylated kinase inhibitor BE‐23372M.