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Guest‐Release Control in Enzyme‐Sensitive, Amphiphilic‐Dendrimer‐Based Nanoparticles through Photochemical Crosslinking
Author(s) -
Raghupathi Krishna R.,
Azagarsamy Malar A.,
Thayumanavan S.
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201101066
Subject(s) - amphiphile , dendrimer , context (archaeology) , chemistry , covalent bond , monomer , fluorescence , micelle , photochemistry , conjugated system , substrate (aquarium) , molecule , combinatorial chemistry , polymer chemistry , organic chemistry , copolymer , polymer , aqueous solution , paleontology , physics , oceanography , quantum mechanics , biology , geology
Stimuli sensitive, facially amphiphilic dendrimers have been synthesized and their enzyme‐responsive nature has been determined with dual fluorescence responses of both covalently conjugated and non‐covalently bound reporter units. These dual responses are correlated to ascertain the effect of enzymatic action on micellar aggregates and the consequential guest release. The release of the guest molecule is conveniently tuned by stabilizing the micellar aggregates through photochemical crosslinking of hydrophobic coumarin units. This photo‐crosslinking is also utilized as a tool to investigate the mode of enzyme–substrate interaction in the context of aggregate–monomer equilibrium.