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Syntheses of Spirocyclic Oxindole‐Butenolides by Using Three‐Component Cycloadditions of Isocyanides, Allenoates, and Isatins
Author(s) -
Li Jian,
Liu Yuejin,
Li Chunju,
Jia Xueshun
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100977
Subject(s) - oxindole , workflow , aryl , chemistry , alkyl , component (thermodynamics) , combinatorial chemistry , computer science , database , organic chemistry , catalysis , physics , thermodynamics
Spiro workflow! Efficient syntheses of spirocyclic oxindole‐butenolides from readily available isocyanides, allenoates, and isatins are disclosed (see scheme; R 1 =alkyl, aryl; R 2 =halide, nitro, methoxy; PG=protecting group). This protocol also allows the insertion of carbon monoxide into organic molecules without the aid of a transition‐metal catalyst after the hydrolysis process.