Syntheses of Spirocyclic Oxindole‐Butenolides by Using Three‐Component Cycloadditions of Isocyanides, Allenoates, and Isatins | Zendy

Li Jian | Zendy; Liu Yuejin | Zendy; Li Chunju | Zendy; Jia Xueshun | Zendy

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Syntheses of Spirocyclic Oxindole‐Butenolides by Using Three‐Component Cycloadditions of Isocyanides, Allenoates, and Isatins

Author(s) -

Li Jian,

Liu Yuejin,

Li Chunju,

Jia Xueshun

Publication year - 2011

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201100977

Subject(s) - oxindole , workflow , aryl , chemistry , alkyl , component (thermodynamics) , combinatorial chemistry , computer science , database , organic chemistry , catalysis , physics , thermodynamics

Spiro workflow! Efficient syntheses of spirocyclic oxindole‐butenolides from readily available isocyanides, allenoates, and isatins are disclosed (see scheme; R 1 =alkyl, aryl; R 2 =halide, nitro, methoxy; PG=protecting group). This protocol also allows the insertion of carbon monoxide into organic molecules without the aid of a transition‐metal catalyst after the hydrolysis process.

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