Water‐Based Hydrogen‐Atom Wires as Mediators in Long‐Range Proton‐Coupled Electron Transfer in Enzymes: A New Twist on Water Reactivity | Zendy

Cárdenas Diego J. | Zendy; Cuerva Juan M. | Zendy; Alías Miriam | Zendy; Buñuel Elena | Zendy; Campaña Araceli G. | Zendy

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Water‐Based Hydrogen‐Atom Wires as Mediators in Long‐Range Proton‐Coupled Electron Transfer in Enzymes: A New Twist on Water Reactivity

Author(s) -

Cárdenas Diego J.,

Cuerva Juan M.,

Alías Miriam,

Buñuel Elena,

Campaña Araceli G.

Publication year - 2011

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201100964

Subject(s) - electron transfer , hydrogen atom , reactivity (psychology) , proton , chemistry , proton coupled electron transfer , ligand (biochemistry) , range (aeronautics) , electron , cofactor , chemical physics , atom (system on chip) , twist , combinatorial chemistry , enzyme , photochemistry , materials science , physics , computer science , biochemistry , receptor , organic chemistry , quantum mechanics , alternative medicine , mathematics , pathology , composite material , embedded system , alkyl , geometry , medicine

Water is a conducting ligand between metal complexes! Water mediates the long‐range proton‐coupled electron transfer between two Cu complexes separated by 11 Å in the peptidylglycine α‐hydroxylating monooxygenase (PHM) cofactor (see scheme). The proposed mechanism, which involves three H‐atom exchanges, accounts for long‐range electron transfer in metalloenzymes, and may be ubiquitous in nature.

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