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Substrate‐Controlled, Phosphine‐Catalyzed Domino Reactions of Activated Conjugated Dienes: Highly Diastereoselective Synthesis of Bicyclic Skeletons
Author(s) -
Ma Jianze,
Xie Peizhong,
Hu Chongchong,
Huang You,
Chen Ruyu
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100881
Subject(s) - domino , catalysis , bicyclic molecule , substrate (aquarium) , phosphine , conjugated system , chemistry , intermolecular force , combinatorial chemistry , cascade reaction , stereochemistry , organic chemistry , biology , molecule , polymer , ecology
A single catalyst, multiple dominos : The intermolecular Rauhut–Currier (RC) reaction of activated conjugated dienes enables unprecedented substrate‐controlled phosphine‐mediated domino reactions by two catalytic models, which generate bicyclic skeletons with high diastereoselectivities (see scheme).