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Paramagnetic Lanthanide Tagging for NMR Conformational Analyses of N‐Linked Oligosaccharides
Author(s) -
Yamamoto Sayoko,
Yamaguchi Takumi,
Erdélyi Máté,
Griesinger Christian,
Kato Koichi
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100856
Subject(s) - glycosidic bond , chemistry , lanthanide , oligosaccharide , disaccharide , stereochemistry , information retrieval , biochemistry , computer science , organic chemistry , ion , enzyme
Sweet measurement : Paramagnetic tags are proposed as new tools for NMR analyses of carbohydrate conformations. A newly designed, lanthanide‐chelating tag can be attached to the common disaccharide core shared among all N‐linked oligosaccharides (see figure) and thereby provide reliable information on the glycosidic‐linkage conformation. This success opens the door to conformational studies of a variety of sugar chains of biological interest.