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Ruthenium Catalysts Containing Rigid Chiral Diamines and Achiral Diphosphanes for Highly Enantioselective Hydrogenation of Aromatic Ketones
Author(s) -
Zhu Qiming,
Shi Dengjian,
Xia Chungu,
Huang Hanmin
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100820
Subject(s) - enantioselective synthesis , ruthenium , catalysis , asymmetric hydrogenation , organic chemistry , chemistry , reactivity (psychology) , noyori asymmetric hydrogenation , diamine , combinatorial chemistry , medicine , alternative medicine , pathology
One chiral element is enough : A new ruthenium catalyst containing a rigid chiral diamine (BIDN) and a commercially available inexpensive achiral phosphane (DPPF) is highly efficient for the enantioselective hydrogenation of ketones (see scheme). High reactivity (S/C up to 100 000) and excellent enantioselectivities (up to 99 % ee ) were obtained.