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In Situ Generation and Intramolecular Schmidt Reaction of Keto Azides in a Microwave‐Assisted Flow Format
Author(s) -
Painter Thomas O.,
Thornton Paul D.,
Orestano Mario,
Santini Conrad,
Organ Michael G.,
Aubé Jeffrey
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100768
Subject(s) - intramolecular force , trifluoroacetic acid , microwave irradiation , microwave , computer science , combinatorial chemistry , flow (mathematics) , in situ , chemistry , stereochemistry , organic chemistry , mathematics , telecommunications , geometry
Go with the flow! A method for conversion of keto halides to lactams by means of sequential azidation and intramolecular Schmidt reaction in a combined flow format is described (see scheme; MWI=microwave irradiation, TFA=trifluoroacetic acid).