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Efficient Copper‐Catalyzed Synthesis of Poly‐N‐Heterocycles Containing Amino Acid Residues
Author(s) -
Liu Tao,
Wang Ruji,
Yang Haijun,
Fu Hua
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100690
Subject(s) - malononitrile , catalysis , amino acid , chemistry , copper , organic chemistry , combinatorial chemistry , biochemistry
An efficient copper‐catalyzed method has been developed for the synthesis of poly‐N‐heterocycles containing amino acid residues. The protocol uses readily available 2‐halobenzamides containing amino acids and their methyl esters, substituted phenylacetonitriles, and malononitrile as the starting materials and the reactions were performed well under mild conditions. The method should provide a novel and useful strategy for synthesis of N‐heterocyclic compounds.