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Asymmetric Formal [3+2] Cycloaddition Reaction of Isocyanoesters to 2‐Oxobutenoate Esters by a Multifunctional Chiral Silver Catalyst
Author(s) -
Song Jin,
Guo Chang,
Chen PengHao,
Yu Jie,
Luo ShiWei,
Gong LiuZhu
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100636
Subject(s) - cycloaddition , enantioselective synthesis , catalysis , selectivity , chemistry , combinatorial chemistry , scheme (mathematics) , organic chemistry , mathematics , mathematical analysis
Silver‐standard selectivity! The first highly enantioselective formal [3+2] cycloaddition reaction of isocyanoesters with 2‐oxobutenoate esters catalyzed by a chiral silver complex proceeded readily under the catalysis of a multifunctional chiral silver complex in high yields and enantiometric excess ( ee ) values of up to 98 % (see scheme).