z-logo
Premium
Exploring the Oxidative Cyclization of Substituted N ‐Aryl Enamines: Pd‐Catalyzed Formation of Indoles from Anilines
Author(s) -
Neumann Julia J.,
Rakshit Souvik,
Dröge Thomas,
Würtz Sebastian,
Glorius Frank
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100631
Subject(s) - oxidative phosphorylation , aryl , catalysis , chemistry , medicinal chemistry , aniline , combinatorial chemistry , organic chemistry , biochemistry , alkyl
The direct Pd‐catalyzed oxidative coupling of two CH‐bonds within N ‐aryl‐enamines 1 allows the efficient formation of differently substituted indoles 2 . In this cross‐dehydrogenative coupling, many different functional groups are tolerated and the starting material N ‐aryl‐enamines 1 can be easily prepared in one step from commercially available anilines. In addition, the whole sequence can also be run in a one‐pot fashion. Optimization data, mechanistic insight, substrate scope, and applications are reported in this full paper.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here