Premium
An Enantioselective Approach to 2,3‐Disubstituted Indolines through Consecutive Brønsted Acid/Pd‐Complex‐Promoted Tandem Reactions
Author(s) -
Duan Ying,
Chen MuWang,
Ye ZhiShi,
Wang DuoSheng,
Chen QingAn,
Zhou YongGui
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100576
Subject(s) - tandem , brønsted–lowry acid–base theory , enantioselective synthesis , alkyl , aryl , chemistry , combinatorial chemistry , catalysis , organic chemistry , materials science , composite material
In tandem : A divergent and enantioselective approach to 2,3‐disubstituted indolines was developed through consecutive Brønsted acid/Pd‐complex‐promoted tandem reactions from simple 2‐substituted indoles and aldehydes in one operation to give up to 98 % ee (see scheme; R 1 =H, F, or Me; R 2 =alkyl; R 3 =aryl or alkyl). Three Brønsted acid promoted steps and two Pd‐catalyzed hydrogenation steps were involved in this process.