An Enantioselective Approach to 2,3‐Disubstituted Indolines through Consecutive Brønsted Acid/Pd‐Complex‐Promoted Tandem Reactions | Zendy

Duan Ying | Zendy; Chen MuWang | Zendy; Ye ZhiShi | Zendy; Wang DuoSheng | Zendy; Chen QingAn | Zendy; Zhou YongGui | Zendy

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An Enantioselective Approach to 2,3‐Disubstituted Indolines through Consecutive Brønsted Acid/Pd‐Complex‐Promoted Tandem Reactions

Author(s) -

Duan Ying,

Chen MuWang,

Ye ZhiShi,

Wang DuoSheng,

Chen QingAn,

Zhou YongGui

Publication year - 2011

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201100576

Subject(s) - tandem , brønsted–lowry acid–base theory , enantioselective synthesis , alkyl , aryl , chemistry , combinatorial chemistry , catalysis , organic chemistry , materials science , composite material

In tandem : A divergent and enantioselective approach to 2,3‐disubstituted indolines was developed through consecutive Brønsted acid/Pd‐complex‐promoted tandem reactions from simple 2‐substituted indoles and aldehydes in one operation to give up to 98 % ee (see scheme; R 1 =H, F, or Me; R 2 =alkyl; R 3 =aryl or alkyl). Three Brønsted acid promoted steps and two Pd‐catalyzed hydrogenation steps were involved in this process.

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