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Luminescent Peptide Labeling Based on a Histidine‐Binding Iridium(III) Complex for Cell Penetration and Intracellular Targeting Studies
Author(s) -
Wang Xiaobo,
Jia Junli,
Huang Zezhu,
Zhou Ming,
Fei Hao
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100568
Subject(s) - intracellular , histidine , peptide , cell penetrating peptide , iridium , cell , luminescence , chemistry , computational biology , biochemistry , biophysics , biology , materials science , enzyme , optoelectronics , catalysis
Lighting up the cell : Peptides that are site‐specifically labeled with a luminescent iridium(III) complex at histidine residues can penetrate cell membranes effectively, showing intracellular distribution and efficient mitochondrial targeting (see figure, CPP=cell‐penetrating peptide, MTS=mitochondria‐targeting sequences).