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A Titanium(III)‐Catalyzed Redox Umpolung Reaction for the Reductive Cross‐Coupling of Enones with Acrylonitriles
Author(s) -
Streuff Jan
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100501
Subject(s) - umpolung , redox , chemistry , catalysis , titanium , cyclopentadiene , alkyl , combinatorial chemistry , organic chemistry , nucleophile
Titanium does the job : 1,6‐Difunctionalized alkyl units, which are traditionally hard to access, have been successfully obtained through a reductive cross‐coupling of activated alkenes catalyzed by Ti III . A plausible reaction mechanism that proceeds through redox umpolung of the enone is briefly discussed (see scheme, Cp=cyclopentadiene).