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Microwave‐Assisted Aminocarbonylation of Ynamides by Using Catalytic [Fe 3 (CO) 12 ] at Low Pressures of Carbon Monoxide
Author(s) -
Pizzetti Marianna,
Russo Adele,
Petricci Elena
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100447
Subject(s) - triethylamine , carbon monoxide , catalysis , carbonylation , microwave irradiation , microwave , stoichiometry , ligand (biochemistry) , combinatorial chemistry , chemistry , atom economy , materials science , organic chemistry , computer science , telecommunications , biochemistry , receptor
The microwave‐assisted aminocarbonylation of ynamides at low pressures of CO is reported. A new class of ( E )‐acrylamides that are potentially suitable for several applications has been regioselectively synthesized after microwave irradiation for only 20 min by using eco‐friendly [Fe 3 (CO) 12 ] as the catalyst precursor and triethylamine as the ligand. This transformation is atom economic as all reactants are used in stoichiometric quantities. Furthermore, the transformation is efficiently applied to the alkoxycarbonylation of alkynes as well. Moreover, running these reactions under microwave irradiation allows the simplification of the reaction conditions with remarkable reductions in time, temperature and gas pressure.