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Synthesis of 5‐Halo‐4 H ‐1,3‐oxazine‐6‐amines by a Copper‐Mediated Domino Reaction
Author(s) -
Hashmi A. Stephen K.,
Schuster Andreas M.,
Zimmer Marc,
Rominger Frank
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100423
Subject(s) - domino , aryl , alkyl , combinatorial chemistry , amine gas treating , chemistry , medicinal chemistry , computer science , organic chemistry , catalysis
Three become one! In one copper‐mediated step, three simple components, including a propargylcarboxamide, a protected amine, and a source of chloride, assemble to give highly functionalized oxazines, which are interesting building blocks for the synthesis of other aminooxazine derivatives (see scheme; R 1 =range of aryl or alkyl groups, R 2 =alkyl, EWG=electron‐withdrawing group).