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Direct One‐Pot Reductive N‐Alkylation of Nitroarenes by using Alcohols with Supported Gold Catalysts
Author(s) -
Tang ChunHong,
He Lin,
Liu YongMei,
Cao Yong,
He HeYong,
Fan KangNian
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100393
Subject(s) - alkylation , catalysis , chemistry , nitro , ligand (biochemistry) , combinatorial chemistry , reductive elimination , organic chemistry , hydrogen , biochemistry , alkyl , receptor
Gold standard support! The direct reductive mono‐ or di‐N‐alkylation of aromatic nitro compounds with alcohols, using a hydrogen‐borrowing strategy, was efficiently promoted by a ligand‐free titania‐supported gold catalyst system (see scheme). A variety of nitroarenes were selectively converted into the corresponding secondary or tertiary amines in good to excellent yields without any co‐catalysts, such as bases and stabilizing ligands.