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Palladium‐Catalyzed Borylation of Aryl Mesylates and Tosylates and Their Applications in One‐Pot Sequential Suzuki–Miyaura Biaryl Synthesis
Author(s) -
Chow Wing Kin,
So Chau Ming,
Lau Chak Po,
Kwong Fuk Yee
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100361
Subject(s) - borylation , palladium , aryl , catalysis , chemistry , indole test , combinatorial chemistry , compatibility (geochemistry) , medicinal chemistry , organic chemistry , materials science , alkyl , composite material
Top of the one‐pots! The first palladium‐catalyzed borylation of aryl tosylates and mesylates is described. The reaction conditions are mild and provide excellent functional‐group compatibility (e.g., R=CN, CHO, COOMe, C(O)R, NH 2 , or NH‐indole; see scheme). Pd/MeO‐CM‐phos allows one‐pot sequential reactions in the preparation of unsymmetrical biaryls.