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Cytotoxicity of Gold(I) N‐Heterocyclic Carbene Complexes Assessed by Using Human Tumor Cell Lines
Author(s) -
Weaver Jennifer,
Gaillard Sylvain,
Toye Caroline,
Macpherson Stephen,
Nolan Steven P.,
Riches Andrew
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100321
Subject(s) - cytotoxicity , carbene , moiety , cisplatin , cytotoxic t cell , chemistry , cell culture , stereochemistry , cancer research , in vitro , combinatorial chemistry , biochemistry , biology , medicine , chemotherapy , genetics , catalysis
Antitumor Au I –NHC : Gold(I) N‐heterocyclic carbene complexes exhibit marked cytotoxicity to human tumor cell lines. The cytotoxicity is dependent on the group bound to the gold–NHC moiety: [Au(OH)(IPr)] ( 1 ) and [Au(IPr)Cl] ( 2 ) are most effective. There was no difference between the cytotoxic effects on normal prostate or breast epithelial cells compared to tumor cells from the same tissue. The active compounds were more potent than cisplatin.