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A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core
Author(s) -
Wu Bin,
Ong Michelle S.,
Groessl Michael,
Adhireksan Zenita,
Hartinger Christian G.,
Dyson Paul J.,
Davey Curt A.
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100298
Subject(s) - nucleosome , chromatin , histone , ruthenium , chemistry , adduct , computational biology , dna , biophysics , biology , biochemistry , catalysis , organic chemistry
His‐tones are not ruth‐less : A ruthenium anticancer agent, RAPTA‐C, was found to associate with chromatin in cancer cells and to form stable, well‐defined adducts in the nucleosome core at specific histone protein sites (see picture). This illuminates the macromolecular binding properties of this antimetastasis agent and indicates potential for developing metallodrugs for site‐selective targeting of chromatin.