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Palladium‐Catalyzed Oxidative Trifluoromethylation of Indoles at Room Temperature
Author(s) -
Mu Xin,
Chen Shujun,
Zhen Xingliang,
Liu Guosheng
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100283
Subject(s) - trifluoromethylation , palladium , reagent , catalysis , chemistry , aryl , oxidative phosphorylation , combinatorial chemistry , photochemistry , organic chemistry , trifluoromethyl , biochemistry , alkyl
Trifluoromethylation of indoles has been performed successfully at room temperature by using a novel palladium‐catalyzed oxidation strategy. In this reaction, PhI(OAc) 2 has been used as an oxidant and TMSCF 3 as a trifluoromethylation reagent (see scheme). A palladium(II/IV) mechanism has been proposed for the formation of the aryl CCF 3 bond.