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Chiral Metallo–Supramolecular Complexes Selectively Induce Human Telomeric G‐Quadruplex Formation under Salt‐Deficient Conditions
Author(s) -
Zhao Chuanqi,
Geng Jie,
Feng Lingyan,
Ren Jinsong,
Qu Xiaogang
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100272
Subject(s) - circular dichroism , g quadruplex , enantiomer , supramolecular chemistry , chemistry , förster resonance energy transfer , rational design , dna , stereochemistry , molecular model , cleavage (geology) , fluorescence , crystallography , biochemistry , biology , nanotechnology , materials science , crystal structure , paleontology , physics , quantum mechanics , fracture (geology)
Chiral molecular recognition of human telomeric DNA is important for rational drug design and developing structural probes of G‐quadruplexes. Here we report that a chiral supramolecular complex can selectively induce human telomeric G‐quadruplex formation and discriminate different G‐quadruplex sequences under salt‐deficient conditions studied by circular dichroism (CD), UV meltings, stopped‐flow spectroscopy, fluorescence resonance energy transfer, enzyme cleavage, and gel electrophoresis. P‐enantiomer induced G‐quadruplex formation is fast and does not require a large excess of P enantiomer. More importantly, this chiral compound induces loop sequence‐dependent G‐quadruplex formation.