Premium
Nickel‐Catalyzed Intramolecular Nucleophilic Addition of Aryl or Vinyl Chlorides to α‐Ketoamides Through CCl Bond Activation
Author(s) -
Hu JinXiu,
Wu Hao,
Li ChuanYing,
Sheng WeiJian,
Jia YiXia,
Gao JianRong
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100256
Subject(s) - intramolecular force , aryl , catalysis , nickel , nucleophile , chemistry , nucleophilic addition , medicinal chemistry , combinatorial chemistry , polymer chemistry , organic chemistry , alkyl
Nickeleophilic addition! The first example of a nickel‐catalyzed direct intramolecular nucleophilic addition of aryl or vinyl chlorides to α‐ketoamides through CCl bond activation is reported, which takes place under mild reaction conditions (see scheme).