Premium
Synthesis of an Advanced Maoecrystal V Core Structure
Author(s) -
Dong Lin,
Deng Lujiang,
Lim Yee Hwee,
Leung Gulice Y. C.,
Chen David Y.K.
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100232
Subject(s) - intramolecular force , cyclopropanation , chemistry , stereochemistry , core (optical fiber) , cleavage (geology) , sequence (biology) , key (lock) , combinatorial chemistry , computer science , organic chemistry , catalysis , biology , paleontology , telecommunications , biochemistry , computer security , fracture (geology)
Get to the core : The synthesis of an advanced structure of the recently reported cytotoxic diterpenoid maoecrystal V ( 1 ) has been accomplished. The key carbon–carbon bond‐forming events feature an intramolecular Diels–Alder reaction, a cyclopropanation/reductive cleavage sequence, and an intramolecular alkylative lactonization reaction. Furthermore, a hydroxyl‐directed hydrogenation was implemented to cast the desired C5 stereochemistry.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom