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Bu 4 NI‐Catalyzed CO Bond Formation by Using a Cross‐Dehydrogenative Coupling (CDC) Reaction
Author(s) -
Chen Long,
Shi Erbo,
Liu Zhaojun,
Chen Shulin,
Wei Wei,
Li Hong,
Xu Kai,
Wan Xiaobing
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100192
Subject(s) - alkyl , halide , catalysis , aryl , chemistry , coupling (piping) , coupling reaction , combinatorial chemistry , medicinal chemistry , organic chemistry , materials science , metallurgy
The crème de la crème! A practical and simple Bu 4 NI‐catalyzed CO bond formation was achieved by using a cross‐dehydrogenative coupling (CDC) reaction with tert‐ butyl hydroperoxide (TBHP) as the ultimate oxidant (see scheme; R 1 =aryl, heteroaryl, alkyl; R 2 , R 3 =alkyl, alkyl halide). This approach is the most straightforward method to date for the synthesis of α‐acyloxy ethers. A plausible mechanism has been proposed.