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Facile Creation of 2‐Substituted Indolin‐3‐ones by Using Primary–Secondary Diamine Catalysts
Author(s) -
Sun Wangsheng,
Hong Liang,
Wang Rui
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100144
Subject(s) - conjugate , scheme (mathematics) , catalysis , diamine , computer science , combinatorial chemistry , chemistry , indole test , primary (astronomy) , organic chemistry , mathematics , physics , mathematical analysis , astronomy
2‐Substitute an indole! The asymmetric organocatalytic conjugate addition of 1‐acetylindolin‐3‐one to enones has been developed. This organocatalytic approach constitutes an easy and efficient method for the direct preparation of 2‐substituted indolin‐3‐ones in high enantioselectivities (see scheme).