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Palladium‐Catalyzed Direct Arylations of Azoles with Aryl Silicon and Tin Reagents
Author(s) -
Han Wei,
Mayer Peter,
Ofial Armin R.
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100037
Subject(s) - aryl , regioselectivity , palladium , tin , catalysis , silanes , reagent , combinatorial chemistry , chemistry , organic chemistry , computer science , silane , alkyl
Regioselective arylations of imidazoles, oxazoles, and thiazoles were achieved by palladium‐catalyzed cross‐coupling with trialkoxy(aryl)silanes or allyltriphenylstannane (see scheme). Addition of ligands or exclusion of moisture was not necessary to obtain C2‐substituted azoles in high yields.