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Enantioselective Gold‐Catalyzed Functionalization of Unreactive sp 3 CH Bonds through a Redox–Neutral Domino Reaction
Author(s) -
Zhou Guanghua,
Liu Feng,
Zhang Junliang
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201100019
Subject(s) - domino , trifluoromethanesulfonate , chemistry , enantioselective synthesis , hydride , catalysis , redox , combinatorial chemistry , selectivity , medicinal chemistry , organic chemistry , hydrogen
Selectivity is golden : The first asymmetric redox–neutral domino reaction catalyzed by gold that results in the direct functionalization of unreactive sp 3 CH bonds has been reported. This method consists of a heterocyclization/1,5‐hydride transfer/cyclization reaction and provides synthetically valuable azepines with high enantioselectivities and in high yields (Tf=triflate; see scheme).