Enantioselective Gold‐Catalyzed Functionalization of Unreactive sp 3  CH Bonds through a Redox–Neutral Domino Reaction | Zendy

Zhou Guanghua | Zendy; Liu Feng | Zendy; Zhang Junliang | Zendy

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Enantioselective Gold‐Catalyzed Functionalization of Unreactive sp 3 CH Bonds through a Redox–Neutral Domino Reaction

Author(s) -

Zhou Guanghua,

Liu Feng,

Zhang Junliang

Publication year - 2011

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201100019

Subject(s) - domino , trifluoromethanesulfonate , chemistry , enantioselective synthesis , hydride , catalysis , redox , combinatorial chemistry , selectivity , medicinal chemistry , organic chemistry , hydrogen

Selectivity is golden : The first asymmetric redox–neutral domino reaction catalyzed by gold that results in the direct functionalization of unreactive sp 3 CH bonds has been reported. This method consists of a heterocyclization/1,5‐hydride transfer/cyclization reaction and provides synthetically valuable azepines with high enantioselectivities and in high yields (Tf=triflate; see scheme).

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