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Inside Cover: A Minimalist NMR Approach for the Structural Revision of Mucoxin (Chem. Eur. J. 46/2010)
Author(s) -
Yan Jun,
Garzan Atefeh,
Narayan Radha S.,
Vasileiou Chrysoula,
Borhan Babak
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201090228
Subject(s) - diastereomer , cover (algebra) , acetogenin , chemistry , coupling constant , stereochemistry , physics , biology , engineering , mechanical engineering , botany , particle physics , annonaceae
Puzzle solved When the spectra of the synthesized structure of mucoxin, a natural product from the Annonaceous acetogenin family, did not match that of the isolated sample, the reason was not as obvious as one might hope. With the proper use of trends observed in NMR chemical shift correlations and coupling constants, as determined using a series of carefully chosen synthesized diastereomers of the possible structure, one can solve the structural puzzle as described by C. Vasileiou, B. Borhan et al. in their Full Paper on p. 13749 ff.