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Cover Picture: A Gram‐Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin (Chem. Eur. J. 37/2010)
Author(s) -
Brasholz Malte,
Macdonald James M.,
Saubern Simon,
Ryan John H.,
Holmes Andrew B.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201090183
Subject(s) - chemistry , regioselectivity , catalysis , stereochemistry , conjugated system , synthon , rhodium , molecule , organic chemistry , polymer
Biologically valuable histrionicotoxin spiropiperidine alkaloids are found in the Colombian poison arrow frog Dendrobates histrionicus (shown on the cover). In their Full Paper on page 11471 ff., J. H. Ryan et al. describe efforts to synthesize an unnatural analogue, perhydrohistrionicotoxin, by combining conventional with microreactor techniques. (Photograph of Dendrobates histrionicus by Mauricio Rivera. Design by Martin Kowalski.)