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Cover Picture: Selective Ruthenium‐Catalyzed N‐Alkylation of Indoles by Using Alcohols (Chem. Eur. J. 12/2010)
Author(s) -
Bähn Sebastian,
Imm Sebastian,
Mevius Kathleen,
Neubert Lorenz,
Tillack Annegret,
Williams Jonathan M. J.,
Beller Matthias
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201090052
Subject(s) - ruthenium , catalysis , chemistry , alkylation , indole test , transfer hydrogenation , cover (algebra) , organic chemistry , hydrogen , combinatorial chemistry , mechanical engineering , engineering
Borrowing hydrogen catalysis for an environmentally benign N‐alkylation of indoles with alcohols is described in a joint effort by M. Beller, J. Williams, and co‐workers in their Communication on page 3590 ff. This novel procedure occurs through an unusual “borrowing hydrogen” methodology by use of the Shvo catalyst. The protocol is operationally simple and mechanistically involves an in situ transfer hydrogenation of the indole.