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Inside Cover: Selective Ruthenium‐Catalyzed Alkylation of Indoles by Using Amines (Chem. Eur. J. 9/2010)
Author(s) -
Imm Sebastian,
Bähn Sebastian,
Tillack Annegret,
Mevius Kathleen,
Neubert Lorenz,
Beller Matthias
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201090034
Subject(s) - alkylation , catalysis , ruthenium , chemistry , indole test , yield (engineering) , combinatorial chemistry , primary (astronomy) , organic chemistry , cover (algebra) , materials science , mechanical engineering , engineering , physics , astronomy , metallurgy
The borrowing hydrogen methodology is active in the transition‐metal‐catalyzed C‐alkylation of indoles with easily available aliphatic amines. This novel atom efficient and selective method for indole alkylation proceeds in the presence of the Shvo catalyst under basic conditions. It constitutes a complementary and valuable method for alkylations and benzylations. Hence, various substrates, including primary, secondary, and even tertiary amines, react in good to excellent yield with the indoles. For more details see the Communication by M. Beller et al. on page 2705 ff.