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Inside Cover: Structure of the Complex of [Ru(tpm)(dppz)py] 2+ with a B‐DNA Oligonucleotide—A Single‐Substituent Binding Switch for a Metallo‐Intercalator (Chem. Eur. J. 8/2010)
Author(s) -
Waywell Philip,
Gonzalez Veronica,
Gill Martin R.,
Adams Harry,
Meijer Anthony J. H. M.,
Williamson Mike P.,
Thomas James A.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201090029
Subject(s) - intercalation (chemistry) , substituent , oligonucleotide , chemistry , dna , crystallography , minor groove , stereochemistry , duplex (building) , inorganic chemistry , biochemistry
The NMR‐derived structure of an achiral [Ru II (dppz)] complex bound to duplex DNA confirms that it intercalates from the minor groove as described in the Full Paper by J. A. Thomas et al. on page 2407 ff. The structure also explains why the nature and position of a single functional group acts as an on/off switch for intercalative binding and DNA light‐switching effects.