Premium
Inside Cover: Reversible Dimerization of EGFR Revealed by Single‐Molecule Fluorescence Imaging Using Quantum Dots (Chem. Eur. J. 4/2010)
Author(s) -
Kawashima Nagako,
Nakayama Kenichi,
Itoh Kohji,
Itoh Tamitake,
Ishikawa Mitsuru,
Biju Vasudevanpillai
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201090008
Subject(s) - epidermal growth factor receptor , quantum dot , molecule , biophysics , cell signaling , chemistry , receptor , fluorescence , cell membrane , cell , fluorescence microscope , membrane , fluorescence lifetime imaging microscopy , signal transduction , nanotechnology , materials science , biology , physics , biochemistry , optics , organic chemistry
Incessant activation of single‐molecule receptors amplifies cell‐signaling. Interactions among membrane proteins are often utilized by cells for regulating various physiological functions. The nanoglow of quantum dots when combined with single‐molecule microscopy and spectroscopy literally lights up as the cell‐signaling by epidermal growth factor receptor (EGFR) laterally propagates through reversible association among activated and inactive dimers of EGFR. For details about the molecular mechanism underlying signaling by EGFR, see the Full Paper by V. Biju et al. on page 1186 ff.