Fluorinated Aromatic Ketones as Nucleophiles in the Asymmetric Organocatalytic Formation of CC and CN Bonds: A Facile Route to the Construction of Fluorinated Quaternary Stereogenic Centers | Zendy

Zhao Yujun | Zendy; Pan Yuanhang | Zendy; Liu Hongjun | Zendy; Yang Yuanyong | Zendy; Jiang Zhiyong | Zendy; Tan ChoonHong | Zendy

Premium

Fluorinated Aromatic Ketones as Nucleophiles in the Asymmetric Organocatalytic Formation of CC and CN Bonds: A Facile Route to the Construction of Fluorinated Quaternary Stereogenic Centers

Author(s) -

Zhao Yujun,

Pan Yuanhang,

Liu Hongjun,

Yang Yuanyong,

Jiang Zhiyong,

Tan ChoonHong

Publication year - 2011

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201003761

Subject(s) - stereocenter , enantioselective synthesis , nucleophile , amination , chemistry , organic chemistry , nucleophilic aromatic substitution , combinatorial chemistry , nucleophilic substitution , catalysis

Highly enantioselective Mannich and α‐amination reactions have been successfully developed using α‐fluorinated aromatic ketones as fluorocarbon nucleophiles in the presence of a bicyclic chiral guanidine (see scheme; Ms=methanesulfonyl). This method is a simple and efficient approach to the construction of fluorinated quaternary stereogenic centers.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research