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Stereodivergent Ruthenium‐Catalyzed Transfer Semihydrogenation of Diaryl Alkynes
Author(s) -
Li Jie,
Hua Ruimao
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201003662
Subject(s) - ruthenium , catalysis , combinatorial chemistry , transfer hydrogenation , chemistry , transfer (computing) , computer science , organic chemistry , parallel computing
[Ru 3 (CO) 12 ]‐catalyzed transfer semihydrogenation of various functionalized diaryl alkynes with N , N ‐dimethylformamide (DMF) and water as hydrogen source affords cis ‐ and trans ‐stilbenes. The stereodivergent approach can be switched by the use of acetic (HOAc) or trifluoroacetic (TFA) acid as additives. The catalytic processes can be applied to the synthesis of analogues of natural products such as cis ‐combretastatin A‐4 and trans ‐resveratrol.