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Pd–NHC Catalyzed Conjugate Addition versus the Mizoroki–Heck Reaction
Author(s) -
Gottumukkala Aditya L.,
de Vries Johannes G.,
Minnaard Adriaan J.
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201003643
Subject(s) - conjugate , aryl , halide , catalysis , chemistry , base (topology) , alkyl , heck reaction , combinatorial chemistry , medicinal chemistry , organic chemistry , mathematics , mathematical analysis
Ace of base : A catalytic system is presented that, solely by choice of the base, selectively switches between conjugate addition and the Mizoroki–Heck reaction of aryl halides with Michael acceptors (see scheme; R, R′=alkyl, aryl). For conjugate addition reactions, this avoids the preparation and use of organometallics.