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Phosphane‐Free Green Protocol for Selective Nitro Reduction with an Iron‐Based Catalyst
Author(s) -
Sharma Upendra,
Verma Praveen Kumar,
Kumar Neeraj,
Kumar Vishal,
Bala Manju,
Singh Bikram
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201003621
Subject(s) - nitro , chemistry , regioselectivity , amide , catalysis , yield (engineering) , nitrile , selectivity , ligand (biochemistry) , selective reduction , combinatorial chemistry , solvent , organic chemistry , medicinal chemistry , biochemistry , alkyl , materials science , receptor , metallurgy
Iron phthalocyanine with iron sulfate has been successfully applied for high chemo‐ and regioselective reduction of aromatic nitro compounds to give the corresponding amines in a green solvent system without using any toxic ligand. The catalytic systems were also compatible with a large range of other reducible functional groups, such as keto, acid, amide, ester, halogen, lactone, nitrile, N ‐benzyl, O ‐benzyl, hydroxy, and heterocycles. In the present study, dinitro compounds have been regioselectively reduced to the corresponding amines with high yield. In most of the cases the conversion and selectivity was greater than 99 % as determined by GC‐MS analysis.