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Organocatalytic Michael–Alkylation Cascade: The Enantioselective Nitrocyclopropanation of Oxindoles
Author(s) -
Pesciaioli Fabio,
Righi Paolo,
Mazzanti Andrea,
Bartoli Giuseppe,
Bencivenni Giorgio
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201003423
Subject(s) - enantioselective synthesis , michael reaction , alkylation , cascade , sequence (biology) , combinatorial chemistry , organocatalysis , chemistry , organic chemistry , computer science , catalysis , biochemistry , chromatography
The spiro saga goes on! The title reaction sequence provides the first enantioselective synthesis of spiro nitrocyclopropyl oxindoles. The method provides easy access to these new, biologically inspired compounds from readily available starting materials (see scheme).