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Gold(I)‐Catalyzed, Highly Diastereoselective, Tandem Heterocyclizations/[3+2] Cycloadditions: Synthesis of Highly Substituted Cyclopenta[ c ]furans
Author(s) -
Gao Hongyin,
Wu Xingxing,
Zhang Junliang
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201003363
Subject(s) - tandem , domino , cationic polymerization , catalysis , chemistry , cascade reaction , combinatorial chemistry , medicinal chemistry , organic chemistry , materials science , composite material
The domino effect : A novel, cationic, gold(I)‐catalyzed [3+2], tandem bicyclization, which provides rapid, efficient, and diastereoselective access to highly substituted cyclopenta[ c ]furans from simple, readily available 2‐(1‐alkynyl)‐2‐alken‐1‐ones and 3‐styrylindoles under mild conditions, is described (see scheme).