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Silicon‐Based Chemistry: An Original and Efficient One‐Step Approach to [ 18 F]‐Nucleosides and [ 18 F]‐Oligonucleotides for PET Imaging
Author(s) -
Schulz Jürgen,
Vimont Delphine,
Bordenave Thomas,
James Damien,
Escudier JeanMarc,
Allard Michèle,
SzlosekPinaud Magali,
Fouquet Eric
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201003234
Subject(s) - oligonucleotide , pet imaging , positron emission tomography , click chemistry , chemistry , silicon , radiochemistry , combinatorial chemistry , nanotechnology , materials science , nuclear medicine , dna , organic chemistry , biochemistry , medicine
Take it eaSi! Nucleosides, dinucleotides, and one oligonucleotide, all modified by click chemistry, have for the first time been directly and very efficiently labeled with 18 F by using a silicon‐based, one‐step approach that opens the way for the development of a new class of positron emission tomography (PET) tracers (see graphic).