Silicon‐Based Chemistry: An Original and Efficient One‐Step Approach to [ 18 F]‐Nucleosides and [ 18 F]‐Oligonucleotides for PET Imaging | Zendy

Schulz Jürgen | Zendy; Vimont Delphine | Zendy; Bordenave Thomas | Zendy; James Damien | Zendy; Escudier JeanMarc | Zendy; Allard Michèle | Zendy; SzlosekPinaud Magali | Zendy; Fouquet Eric | Zendy

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Silicon‐Based Chemistry: An Original and Efficient One‐Step Approach to [ 18 F]‐Nucleosides and [ 18 F]‐Oligonucleotides for PET Imaging

Author(s) -

Schulz Jürgen,

Vimont Delphine,

Bordenave Thomas,

James Damien,

Escudier JeanMarc,

Allard Michèle,

SzlosekPinaud Magali,

Fouquet Eric

Publication year - 2011

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201003234

Subject(s) - oligonucleotide , pet imaging , positron emission tomography , click chemistry , chemistry , silicon , radiochemistry , combinatorial chemistry , nanotechnology , materials science , nuclear medicine , dna , organic chemistry , biochemistry , medicine

Take it eaSi! Nucleosides, dinucleotides, and one oligonucleotide, all modified by click chemistry, have for the first time been directly and very efficiently labeled with 18 F by using a silicon‐based, one‐step approach that opens the way for the development of a new class of positron emission tomography (PET) tracers (see graphic).

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