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Multicomponent Synthesis of Chiral Sulfinimines
Author(s) -
Roe Caroline,
Hobbs Heather,
Stockman Robert A.
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201003222
Subject(s) - template , enantiomer , combinatorial chemistry , chemistry , materials science , stereochemistry , nanotechnology
Two oxathiozolidine‐ S ‐oxide templates have been developed and used in a four‐component coupling protocol for the synthesis of a wide range of chiral sulfinimines in high enantiomeric excesses. The templates can be synthesized from cheap commodity chemicals in three steps in high yields. Furthermore the template is easily recovered in high yields for recycling.