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Diastereoselective Chain‐Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly
Author(s) -
Carter Catherine F.,
Lange Heiko,
Sakai Daiki,
Baxendale Ian R.,
Ley Steven V.
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201003148
Subject(s) - elongation , microreactor , polyketide , chain (unit) , assembly line , chemistry , combinatorial chemistry , molecule , sequence (biology) , nanotechnology , computer science , biological system , materials science , catalysis , organic chemistry , physics , engineering , biology , biosynthesis , biochemistry , mechanical engineering , metallurgy , ultimate tensile strength , astronomy , enzyme
Diastereoselective chain‐elongation reactions are important transformations for the assembly of complex molecular structures, such as those present in polyketide natural products. Here we report new methods for performing crotylation reactions and homopropargylation reaction s by using newly developed low‐temperature flow‐chemistry technology. In‐line purification protocols are described, as well as the application of the crotylation protocol in an automated multi‐step sequence.