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Enantioselective Synthesis of Axially Chiral 1‐Arylisoquinolines by Rhodium‐Catalyzed [2+2+2] Cycloaddition
Author(s) -
Sakiyama Norifumi,
Hojo Daiki,
Noguchi Keiichi,
Tanaka Ken
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201003134
Subject(s) - enantioselective synthesis , cycloaddition , axial symmetry , rhodium , catalysis , combinatorial chemistry , chemistry , organic chemistry , mathematics , geometry
It's all in the application! An enantioselective synthesis of axially chiral 1‐arylisoquinolines has been achieved, which involves a rhodium‐catalyzed [2+2+2] cycloaddition of diphenylphosphinoyl‐substituted 1‐arylisoquinolines (see scheme). The new diphenylphosphinoyl‐substituted axially chiral 1‐arylisoquinolines were successfully derivatized to the corresponding axially chiral P,N ligand and Lewis base catalyst.