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The “Bridge” Game: Role of the Fourth Player in Chiral Recognition
Author(s) -
Fraschetti Caterina,
Pierini Marco,
Villani Claudio,
Gasparrini Francesco,
Mortera Stefano Levi,
Filippi Antonello,
Speranza Maurizio
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201002828
Subject(s) - bridge (graph theory) , rigidity (electromagnetism) , computer science , point (geometry) , information retrieval , human–computer interaction , chemistry , combinatorial chemistry , physics , medicine , mathematics , quantum mechanics , geometry
A new team player : The “three‐point interaction” model, which is usually employed to rationalize chiral recognition, does not account for the amazing enantioselectivity measured for the receptors of many proteic acceptors. Gas‐phase experiments have indicated that at least a fourth “player” must be considered: the rigidity that a receptor opposes to distortions of its cavity resulting from noncovalent interactions with a chiral molecule (see picture).