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Investigation of a Series of Silver–N‐Heterocyclic Carbenes as Antibacterial Agents: Activity, Synergistic Effects, and Cytotoxicity
Author(s) -
Roland Sylvain,
Jolivalt Claude,
Cresteil Thierry,
Eloy Laure,
Bouhours Pascale,
Hequet Arnaud,
Mansuy Virginie,
Vanucci Corinne,
Paris JeanMarc
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201002812
Subject(s) - cytotoxicity , chemistry , antibacterial activity , ciprofloxacin , combinatorial chemistry , catalysis , microbiology and biotechnology , bacteria , in vitro , organic chemistry , biochemistry , antibiotics , biology , genetics
The power of silver! Silver–N‐heterocyclic carbenes (NHCs), commonly used in catalysis, exhibit high antibacterial activity. Some are efficient at low concentrations against resistant strains of S. aureus that cause major problems to public health. Due to synergistic effects, silver–NHCs can also restore the activity of ciprofloxacin against resistant S. aureus NorA at very low concentrations (see graphic).