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An Efficient, Ligand‐Free, Heterogeneous Supported Copper Hydroxide Catalyst for the Synthesis of N , N ‐Bicyclic Pyrazolidinone Derivatives
Author(s) -
Yoshimura Kazuaki,
Oishi Takamichi,
Yamaguchi Kazuya,
Mizuno Noritaka
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201002793
Subject(s) - bicyclic molecule , cycloaddition , hydroxide , catalysis , ligand (biochemistry) , terminal (telecommunication) , chemistry , copper , combinatorial chemistry , medicinal chemistry , organic chemistry , computer science , telecommunications , biochemistry , receptor
Truly heterogeneous with retention of its high performance : The 1,3‐dipolar cycloaddition of azomethine imines to terminal alkynes was efficiently promoted by the easily prepared, inexpensive, supported copper hydroxide, Cu(OH) x /Al 2 O 3 . Various kinds of azomethine imines and terminal alkynes could be utilized as dipoles and dipolarophiles, respectively, to form the corresponding N , N ‐bicyclic pyrazolidinone derivatives in high yields.